Understanding Morquio B

Welcome to our guide to understanding Morquio B. This resource aims to provide clarity and insight into the complexities of this disease.

What is Morquio B?

Morquio B, also called Mucopolysaccharidosis IVB, is a rare storage disorder with a prevalence of 1 in 250,000 – 1,000,000 live births. It is caused by a distinct mutation in the GLB1 gene. This condition involves birth defects and complications with long bones and the spine, as well as cartilage and various other organs. The condition causes short stature with a disproportionally short body.

Over time the condition progresses and mobility becomes more of a challenge. Hip and knee replacement are common as well as other orthopedic related issues. Spinal cord compression can become an issue over time. There is no treatment, and no cure.

Without a treatment, the disease continues to progress, and the condition becomes more complicated and painful.

What You Can Do

Your Participation

We need everyone with a diagnosis of Morquio B to find the courage to reach out to us and help us. Participation is the key to gathering important information to find a treatment, and hopefully one day, find a cure. Please join our efforts.


Research takes funding. With our efforts, and your generous donations over the last 15 years, we are closer than ever to finding a treatment. Please continue to support us by making a tax deductible donation to UBC Medicine.

Take the Survey

We will be starting a new research project very soon and your participation is really important. Our website is here to link patients with physicians who can help all of us and anyone’s participation in a survey is completely confidential.